Blood Collection Guidelines for Macaques
Macaques have a blood volume of approximately 66 ml/kg. 10% of this volume may be taken during a 2-week period or 15% may be taken with a 4-week recovery period (see table below).
Table I: Blood Sampling Volumes and Recovery Periods for macaques
% Circulatory Blood Volume Removed
|
mL/kg Blood Volume Removed |
Approximate Recovery Period
|
10% |
6.6 |
2 Weeks |
15% |
10 |
4 Weeks |
Example:
For a 5 kg macaque: Up to 50 mLs of blood could be removed at one or multiple points during a 2 week period, but no additional blood should be taken during the subsequent 4 weeks. However, if 33 mLs or less of blood is taken during a 2 week period, an additional volume of up to 33 mLs could be taken during the subsequent 2 week period.
NCI Animal Care and Use Committee - Approved 10/28/2004
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