| 02L06 |
LOU/MN
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| Origin: |
To N in 1975 from Bazin at F? In 1970 Bazin and Beckers started
breeding LOU rat ancestors from various stocks kept at Univerisite
Catholique de Louvain (probably of Wistar origin); from 28 lines
bred in parallel, LOU/M was selected for low immunocytoma incidence
and LOU/C for high immunocytoma incidence. (045) |
| Genetics: |
c
Albino
LOU/MN rats are histocompatible with LOU/CN rats.
Genes:
RT1y
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| Notes: |
Information is included from LOU/MWsl; information from references
that refer to LOU/Wsl is included under LOU/CN if the immunocytoma
incidence is high. |
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| Diseases |
| Neoplastic (Spontaneous): |
| |
- Immunocytomas developed in 0.7% of males and 2.1% of females,
a rate comparable to other rat strains with the exception of LOU/C.
(050)
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| Other Characteristics |
| Immunologic: |
| |
- High reaginic antibody serum levels were produced by administration
of ovalbumin with Bordetella pertussis as adjuvant; response was
similar to hooded Lister rats, a very high responder strain. (043)
- Passive cutaneous anaplylaxis (PCA) reactivity was completely
abolished in rats bearing an IgE immunocytoma, but only slightly
suppressed in rats bearing an
IgG20
- immunocytoma; reversed PCA reactivity was only slightly decreased
in both. PCA reactivity in normal LOU/M rats was comparable to
Wistar rats for the pooled
regain-rich sera against Nip-postrongylus brasiliensis obtained from Wistar
rats.
(512)
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| Physiologic: |
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- Circadian rhythms of excretion of amino acids, polyamines,
and light chains were studied in rats bearing an immunocytoma;
the rhythms are of interest as potential markers for the chronotherapy
of cancer. (243)
- The effect of methlprednisolone sodium succinate upon a transplantable
immunocytoma was studied under conditions standardized for rhythmometry.
(384)
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