| 01S50 |
N:NIH(S)
NIH |
|
| Origin: |
Derived from N:GP(S) colony in 1936. |
| Genetics: |
c
Albino |
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|
| Diseases |
| Neoplastic (Induced): |
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- An N-tropic virus induced from BALB/c embryo fibroblasts (BALB;
virus-1) induced myeloid metaplasia. (341)
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| Non-Neoplastic (Spontaneous): |
| |
- A variant of Citrobacter freundii was identified as the etiologic
agent of transmissible murine colonic hyperplasia. (038)
|
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| Non-Neoplastic (Induced): |
| |
- Transmissible murine colonic hyperplasia was induced by oral inoculation
with Citrobaxter freundii variant 4280; mortality was low in NIH
Swiss mice but mucosal hyperplasia was greater than in three inbred
strains tested. Hyperplasia was most severe 16 days after inoculation,
then regressed; hyperplastic response appeared to be a defense mechanism
of replacing infected mucosal epithelial cells with newly migrated,
uninfected epithelium. (337,037)
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| Other Characteristics |
| Immunologic: |
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- Although no infectious virus was present, NIH Swiss mice consistently
and independent of age were positive for gs antigen (negative for
GIX antigen). (607)
- Used extensively for pertussis HSF testing. (088)
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|
| Biochemical: |
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- Two murine leukemia virus proteins, p30 and reverse transcriptase
found in gravid uteri throughout gestation; both proteins were most
concentrated on first day after mating, decreased by 90% or more
near mid-gestation, and increased greatly by first day after parturition.
(712)
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| Misc: |
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- Infectious leukemia virus has never been detected; iododeoxyuridine
induction of embryo tissue cultures did not yield virus. (607)
- Prototype Fv-1n stock. (410)
- A survey of allozyme poloymorphism at 36 loci indicated strikingly
similar gene structures in NIH Swiss-Webster, CD-1, and a
Swiss-Webster colony from Eppley
Institute, and no evidence of random fixation of segregating allozyme
alleles. Gpi-1b was fixed in N:NHI(S); Got-2 (0.97b, 0.03a) and
Id-1 (0.97a, 0.03b)
were headed for fixation. (515)
- Carries gene for short ear (se), bent tail (bt), and GPD-1b.
(246)
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