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Animal Production Program
| 01S30 |
SJL/N
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| Origin: |
To N 1969 from Herberman as penbred stock, then brother-sister
mated. Developed from Swiss-Webster stock brought to Jackson Lab
between 1938 and 1943. Penbred until 1955 when brother-sister matings
started. |
| Genetics: |
A, c
Albino
Genes:
Car-2b, Ce-2a, Es-1b, Es-3c, Es-10b, Gpd-1b, Gpi-1a, Hbbs,
Idh-1b, Lva, Mod-1a, Mup-1a, Pep-3b, Pgm-1b, Trfa
Hc1, H-2Ds, H-2Ks, Lyb-2c, Lyt-1b, Lyt-2b, Lyt-3b, Thy-1b, Tlaa.
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| Diseases |
| Neoplastic (Spontaneous): |
| |
- Reticulum cell sarcoma in 70-80% of males and females over 1
year of age; multicellular type B neoplasms resemble Hodgkin’s
disease. As neoplasms develop, YG1 and YG2 paraproteinemia appear.
(247,773)
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| Neoplastic (Induced): |
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- In comparison with other inbred strains, SJL is susceptible
to Friend S and B viruses. (370)
- Urethane only slightly leukemogenic, but 7, 12-dimethylbenzanthracene
increased lymphocytic neoplasms from 2% to 83% in young mice.
(159,247)
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| Other Characteristics |
| Immunologic: |
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- Neither of 2 leukemia-specific cellular antigens, G (Gross) or
TL (thymus-leukemia) were detected. (159)
- Only 5% of normal amount of λ light chains synthesized in serum
immunoglobulins. In contrast to other strains with Ig-1b allotype,
SJL expresses only traces of
NPb idiotype in their anti-NP antibodies, the L chains of which are almost
exclusively of the chi type; hybridization studies indicated that
this failure was due to
the λ low phenotype. (325)
- Responsive to pertussis HSF. (778,500)
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| Misc: |
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- High resistance to whole body X-irradiation. (502)
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