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Animal Production Program
| 01F50 |
FVB/N
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| Origin: |
In 1966, outbred Swiss mice at the National Institutes of Health were selectively bred
for either resistance or sensitivity to histamine challenge post pertussis vaccination.
In 1975 by continuous sib-matings of a group of animals separated from HSFS/N at about F8 was
found to carry the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain.
The FVB/N strain resulted from inbreeding this line for the Fv1b allele. Due to the
prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly
used for transgenic injection.
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| Genetics: |
Genes:
Car-2b, Ce-2a, Es-1b, Es-3c, Es-10a, Gpd-1b, Gpi-1b, Gusb, Hbbd,
Idh-1a, Mod-1a, Mup-1c, Pep-3b, Pgm-1a, Trfb
Hc1, Lyt-1b, Thy-1a.
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| Other Characteristics |
| Misc: |
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