Received by NCI from Allan Bradley at Baylor College
of Medicine in 2000. The C57BL/6-cBrd/cBrd strain is a spontaneous
albino mutant coisogenic C57BL/6 strain. The mice contain a mutation
in the c-(tyrosinase gene) and when homozygous for
the mutation the coat color of the mice is albino rather than black
(See Liu, P. et al Genetics.1998 150:1155-68).
This mouse line is therefore useful as a source of albino C57BL/6
embryos for generating chimeras with either C57BL/6 (Black) ES
cells, such as Bruce-4, (Seong E, et al Trends Genet. 2004 20:59-62)
or 129 derived ES cells, where both the Black and Agouti coat
colors of the ES cells can be readily observed against the albino
host coat color.
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