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Animal Production Program
| 01C71 |
C57BL/10ScN
(C57BL/10, B10, C57 / 10ScBs) |
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| Origin: |
To N 1953 from Snell at F35. See C57BL/KaLwn – 15, but from
Russell to Scott at F26, then to Snell. |
| Genetics: |
a, B, C
Intense black
Genes:
Car-2a, Ce-2a, Cs-1g, Es-1a, Es-3a, Es-10a, Gpd-1a, Gpi-1b, Hbbs,
Idh-1a, Lvc, Mod-1b, Mup-1b, Pep-3a, Pgm-1a, Trfb
Hc1, H-2Db, H-2Kb, Lyt-1b, Lyt-2b, Lyt-3b, Thy-1b, Tlab.
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| Diseases |
| Neoplastic (Spontaneous): |
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- Very low mammary tumor incidence. (680)
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| Neoplastic (Induced): |
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- In comparison with other inbred strains, C57BL/10 is resistant
to Gross, Bittner, Friend S and B viruses, and relatively resistant
to Tennant virus. (370)
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| Non-Neoplastic (Induced): |
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- Relatively resistant to induction of cleft palate by cortisone.
(067)
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| Other Characteristics |
| Immunologic: |
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- Macrophages from BDG-infected, LPS-unresponsive C57BL/10ScCR
mice were not tumoricidal in vitro, but cells from BCG-infected
LPS-responsive C57BL/10Sn from Jackson lab were. (608)
- High interferon serum levels after induction by Newcastle disease
virus. (696)
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| Physiologic: |
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- High resting plasma steroid levels, and responds to acute stress
by prolonged elevation. (398)
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| Behavioral: |
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- High preference for ethanol and for morphine presented in a saccharine
vehicle. (794)
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