a, B, C
Intense black
Genes:

Car-2^a, Ce-2^a, Cs-1^g, Es-1^a, Es-3^a, Es-10^a, Gpd-1^a, Gpi-1^b, Gus^b, Hba^a, Hbb^s, Idh-1^a, Lv^b, Mod-1^b, Mup-1^b, Pep-3^a, Pgm-1^a, Trf^b
Hc¹, H-2D^b, H-2K^b, Lyb-2^b, Lyt-1^b, Lyt-2^b, Lyt-3^b, Thy-1^b, Tla^b.

• Very low incidence of mammary tumors. (274)

• More than 75% developed pulmonary metastases within 50 days of amputation of legs with autochthonous 3-methylcholanthrene-induced sarcomas providing a useful model for studies of metastases and evaluation of cancer therapy in a minimal residual disease setting. (790)
• N-butylnitrosourea induced leukemia in 91% of C57BL/6J mice; thymic lymphoblastic, 0-alloantigen-positive (T cell) leukemia predominated with a few cases of non-thymic or stem cell leukemia. Thymectomy reduced the incidence to 64%. (659)
• 3-Methylcholanthrene induced brain tumors in 60% of males. (404)
• Dietary acetylaminofluorene or chlordane induced elevated 0-fetoprotein levels and malignant hepatic lesions. (049)
• In comparison with other inbred strains, C57BL/6 is resistant to Gross, Tennant, and Friend B viruses. (370)

• No dystrophic cardiac calcinosis detected in either sex. (160)
• Intestinal volvulus in a small percentage. (140)

• Incidence of cortisone-induced cleft palate much higher on one commercial diet than on another. (464)
• Relatively resistant to ectromelia. (632)
• Susceptible to infection with Leishmania tropica, but no clinical signs of disease. (063)
• Benzo(a)pyrene administration at day 7 or 10 of gestation caused in utero toxicity and teratogenicity more in C57BL/6 thant in Akr mice. Allelic differences at the Ah locus in the fetus were correlated with dysmorphogenesis. (664)

• BCG pretreatment accelerated the recovery of granuloctye counts after cyclophosphamide-induced leukopenia. (386)
• Delayed hypersensitivity to methylated serum albumin was enhanced by cycloposphamide in young, but not old mice. (469)
• High interferon production after induction with Newcastle disease virus or mammary tumor virus. (131)
• Responsive to pertussis HSF. (778,500)
• Two Lyt differentiated thymocyte populations were detected: one with Lyt-1⁺ and one with Lyt 123⁺. (445)

• Aryl hydrocarbon hydroxylase is inducible by 3-methylcholanthrene and other polycyclic hydrocarbons. The “responsive” Ah^b allele is present. (404,403)
• Morphine increased 3-methoxytyramine and cyclic AMP levels in striatum. (561)
• Liver alcohol dehydrogenase and aldehyde dehydrogenase activities 30% and 300% greater, respectively, than those of DBA/2. (299)

• High preference for alcohol and for morphine presented in a saccharin vehicle. (794)

• Survival time ws significantly shortened by the intraperitoneal, but not oral administration of benzo(a)pyrene. (737)
• 3-Methylcholanthrene was more toxic to C57BL/6N primordial oocytes than to DBA/2N oocytes. (447)
• Resistant to audiogenic seizures at all ages, but susceptibility enhanced by treatment with excess thyroxine. (647,646)
• Less sensitive to analgesic action of morphine than DBA/2 and locomotor response is higher. (561)
• Resistant to toxic effects of chloroform. (127,097)