A, B, C, Xid
Agouti (wild type)
Genes:

Car-2^a, Ce-2^b, Es-1^b, Es-3^c, Es-10^b, Gpd-1^b, Gpi-1^b, Gus^b, Hbb^d, Idh-1^b, Lv^a, Mod-1^b, Mup-1^a, Pep-3^b, Pgm-1^b, Trf^a
Hc¹, H-2D^k, H-2K^k, Lyb-2^b, Lyt-1^a, Lyt-2^a, Lyt-3^b, Thy-1^a, Tla^b.

• Lethal dose 50 of Salmonella typhimurium for CBA/N was 1000-fold less than for CBA/caHN; the increased susceptibility was X-linked from F₁ studies. (514)
• Plasmodium yoelii and Babesia microti infections were more severe and lasted longer in defective F₁ males than in normal males. (334,313)

• The CBA/N mouse carries an X-linked recessive defect expressed in B lymphocytes. (011,307)
• Grafts of fetal liver from CBA/H-T6T6 into irradiated or unirradiated immunodeficient CBA/N mice indicated that CBA/N mice are deficient in a category of pre-B cells which are found in fetal liver. (532)
• Most of the functional behavior of B cells can be explained by a deletion of a mature B cell subset. (491,637,533)
• B lymphocytes in spleen are reduced in number. (636)
• B cells with high IgD.IgM ratios are absent. (832)
• B cells are Lyb 3-, Lyb 5-, and Lyb 7-. (104,001,717)
• B cell surfaces have low Mls determinants and low C3 receptors. (491,001,634)
• No antibody formed in response to rl.rC. (633)
• B cells from male and female (CBA/N x CBA/CaJ)F1 were receptive to T cells help from female F₁ T cells, but male T cells could not augment polyclonal B cell responses of either male or female F₁ mice to LPS, suggesting an intrinsic T cell defect. (224)
• B cells activated by both DNP-LPS and DNP-chicken gamma globulin are rendered tolerant by prior exposure to DNP-Ficoll, implying possession of a B cell type not found at any stage during ontogeny o normal mice. (443)
• When DNP-hemocyanin is administered after DNP-MGG, B cells are unresponsive to subsequent challenge with DNP-hemocyanin, mimicking 3-5 day neonatal B cells. (459)
• No anti-PC IgM or IgG antibodies produced against phosphorylcholine conjugated T-dependent or T-independent antigens, but IgE antibodies to PC-determinant produced when immunized with PC-keyhole limpet hemocyanin. (365)
• Immature B cells wre functionally indistinguishable from normal immature cells, in that both could be triggered to respond to thymus-independent antigens, provided they were supplied with helper T cells, supporting the idea that the CBA/N B cells have deviated during development so that only thymus-dependent B cells develop. (414)
• Fail to produce at least some seta of high affinity antibodies after immunization with sheep erythrocytes (SRBC). (307)
• Primary IgM anti-SRBC response is 10-50% of normal, and primary IgG anti-SRBC response is less than 10% of normal. (635)
• No response to DNP-lysyl-Ficoll, TNP-Ficoll, or TNP-dextran. (637,490,716)
• IgM response to type III pneunococcal polysaccharide (LPS) was extremely low, and response to TNP-LPS was low. (011,560)
• Male and femal x-linked responsiveness to Type III pneumococcal polysaccharide (SSS-III) differ. Both produce an extremely low antibody response to SSS-III but females tend to respond slightly better than males as measured by SSS-III specific PFC. (011)
• Functional colony-forming B cells are entirely lacking. (360)
• CBA/N mice have high natural killer cell activity as do other CBA sublines which do not have the X-linked defect. (624,625)
• The X-linked defect of T-independent immune response was completely expressed in CBA/N x NZB mice, suggesting that the NZB B cell abnormality resulting in excessive IgM production occurs in the B cell population affected by the X-linked defect. (731)
• Although the B-cell response to bromelain-treated mouse erythrocytes is under sex-linked control, low levels of anti-BrMRBC PFC were induced by either specific (17XL Plasmodium yoelii) or nonspecific mechanisms (LPS), and the defect was largely overcome with age in both homozygous and hemizygous mice, probably as a result of environmental stimulation. (597)
• Response to SRBC and LPS increased markedly with age, and spleen cells showed a distinct age-related increase in the percentage of surface lg+ cells. (792)