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Animal Production Program
| 01C40 |
CBA/CaHN
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| Origin: |
To N 1973 from Potter at F36+. Strong (1920) from cross of Bagg
albino female to DBA male. Strains C, C3H, C121, and CHI originated
from this cross. Sent to Haldane and Gruenberg from Little in 1932,
thence to Carter in 1947, to Harwell in 1954. |
| Genetics: |
A, B, C
Agouti (wild type)
Genes:
Car-2a, Ce-2b, Es-1b, Es-3c, Es-10b, Gpd-1b, Gpi-1b, Gusb, Hbbd,
Idh-1b, Mod-1b, Mup-1a, Pep-3b, Pgm-1a, Trfa
Hc1, H-2Dk, H-2Kk, Lyb-2b, Tlab.
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| Diseases |
| Neoplastic (Spontaneous): |
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- Mammary tumor frequency moderate. (237)
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| Non-Neoplastic (Spontaneous): |
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- Absence of one or more third molars in 18% of males and females.
(235)
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| Non-Neoplastic (Induced): |
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- Highly susceptible to Edmonston strain of measles virus.
(513)
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| Other Characteristics |
| Biochemical: |
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- Acute ethanol administration activated liver tryptophan pyrrolase,
and decreased brain tryptophan metabolism. (028)
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| Misc: |
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- Arachidonic acid depressed thymus weight; thymolysis inhibited
by indomethacin which blocks converstion of arachidonic acid into
prostaglandins. (456)
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