The BALB/c nude strain was received from the NIH Animal Genetic Resource in 1980. Received by NCI in 1982 from NIH. Tissues from the BALB/c nude can be transplanted onto normal BALB/c mice. The autosomal recessive nude gene in homozygous ( nu/nu) mice causes the lack of fur and an abnormal thymus. The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues. Heterozygous ( nu/+) animals carry the recessive nude gene on one chromosome only and therefore have a normal thymus triggered immune system.
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