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Animal Production Program
| 01B05 |
BALB/cAnN
(C, Balb C, C/Andervont) |
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| Origin: |
To N 1951 from Andervont at F72. To MacDowell in 1923 who started
inbreeding for Bagg. To Snell in 1932 at F26 who added the c, to
Andervont in 1935. |
| Genetics: |
A, b, c
Albino
Genes:
Car-2b, Ce-2a, Cs-1a, Es-1b,
Es-3a, Es-10a, Gpd-1b, Gpi-1a,
Gusa, Hbab, Hbbd,
Idh-1a, Lva, Mod-1a, Mup-1a,
Pep-3a, Pgm-1a, Trfb
Hc1, H-2Dd, H-2Kd, Lyb-2b, Lyt-1b, Lyt-2b, Lyt-3b, Thy-1b, Tlac.
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Disease
Model: |
IgA immune complex nephropathies, such as berger’s disease
and Henoch-Schoenlein Purpura. (584) |
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| Diseases |
| Neoplastic (Spontaneous): |
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- Mammary tumor incidence low, but increased when mammary tumor
virus introduced. (274)
- Incidence of tumors in BALB/cAnDe female breeders at 17-19 months:
22% mammary gland (adenocanthoma most frequent), 10% reticulum
cell sarcoma (mostly type
B), and 26% pulmonary tumors. (126)
- The total incidence of neoplasms (94%) reported in aging virgin
BALB/cAnNBdf mice was considerably higher than that from other
BALB/c studies, largely due
to the high incidence of adrenal cortical tumors (29%), lung tumors (32%),
and reticulum cell sarcoma (61%). Vascular tumors (5%) and myoepitheliomas
(3%) are
rare in other strains of mice, but have also been reported for other BALB/c
mice. (108)
- The high incidence (60-70% in both sexes) of kidney neoplasms
reported in BALB/cfCd has not been noted in other BALB/c substrains.
(108)
- Moderate incidence of leukemia, late in life, due to endogenous
Type C virus. (089)
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| Neoplastic (Induced): |
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- Interstitial cell testicular tumors and vaginal carcinomas
induced by diethylstilbestrol implants; gross lesion of the testis,
but not pituitary induced by dietary diethylstilbestrol (C57BL/6N).
(232,013)
- Susceptible to induction of plasmacytomas by mineral oil or
pristine. (551)
- 3-Methylcholanthrene increased the incidence of pulmonary
adenomas to 50–62%
in males and females and lymphomas to 20–31%. (004)
- Urinary bladder carcinomas of the transitional cell type were
induced in females, but not males, treated with 2-napthylamine
and cyclophosphamide. (823)
- Subcutaneous connective tissue from BALB/c produced tumors
after growth in petri dishes; latent period before tumor appearance
was inversely proportional
to time
in tissue culture. (068)
- In comparison with other inbred strains, BALB/c is susceptible
to Gross, Tennant, Vaccinia, and Friend B viruses, and relatively
resistant to Friend
S virus.
(370)
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| Non-Neoplastic (Spontaneous): |
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- Aging virgin BALB.cAnNBdf mice had a high incidence (27-74%)
of uterine and mammary hyperplasia, hyperplastic nodules of the
adrenal cortex, glomerulosclerosis, and auricular thrombosis;
and a moderate incidence (8-21%) of ovarian cysts, arteriosclerosis,
ovarian endometriosis, and calcification of organs, principally
the heart. (108)
- Dystrophic cardiac calcinosis in BALB/cAnNlcr mice was almost
exclusively epicardial, with equal frequency and severity in
mated males and females; virgin females had the highest incidence
of 5 strains tested. Renal calcinosis was rare. (160)
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| Non-Neoplastic (Induced): |
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- Glomerulonephritic changes were induced by immune complexes formed
either in vitro or in vivo with polymeric (but not monomeric) IgA
from MOPC-315 myeloma. C3 was not essential for the induction of
renal injury although the immune complexes fix C3. (584)
- Pneumocystis carinii pneumonia was produced by the
administration of corticosteroids, a low protein diet, and tetracycline
in the
drinking water. (772)
- Infection with Leishmania tropica yields a suitable model for
experimental leishmaniasis. (063)
- Susceptible to toxoplasmosis. (246)
- Uterine cervical and vaginal lesions increased after treatment
with norethynodrel plus mestranol (progestin plus estrogen).
(275)
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| Other Characteristics |
| Immunologic: |
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- Expression of XenCSA is low on thymic and splenic lymphocytes.
(488)
- Lacks the autosomal dominat gene which confers hybrid resistance
to BALB/c plasmacytoma MPC-11, and is susceptible to tumor take.
(768)
- Allergenicity of concanavalin A is low is this strain. (468)
- Treatment of BALB/c with anti-idiotype Ab against T15 idiotype
produced immunologic tolerance to PC antigen, with no compensatory
increase in anti-PC antibody
bearing other idiotypes. (107,711)
- Phenotypic expression of AKR MuLv gp 71 is late. (395)
- BALB/c and C3H viral loci are allelic and linked to PGM 1 on
chromosome 5. (316,317)
- Immune response (PFC) to dinitrophenyl bovine serum albumin
is high. (321)
- Susceptible to mouse hepatitis virus 3 infection; disease
is acute or chronic depending on dose. (405)
- Low serum interferon levels after induction by Newcastle
disease virus or mouse mammary tumor virus. (131)
- BALB/cAnN, like BALB/cBy has Qa-2- and Qa-3- specificities.
(190)
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