This workshop will be the eighth biennial gathering of basic researchers and clinical investigators focused exclusively on studies of molecular aspects of myeloid stem cell development, myeloid biology, and leukemogenesis. Topics will include stem cells, regulation of myelopoiesis through signal transduction and transcription factors, myelodysplastic syndrome/myeloproliferative disease, and epigenetic alterations in leukemia. For a summary of the previous meeting held in 2007, see Wolff et al. Exp. Hematol. 36:523, 2008.